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Acromegaly

Somatotroph adenoma; Growth hormone excess; Pituitary giant (in childhood)

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Acromegaly is a condition in which there is too much growth hormone (GH) in the body.

Causes

Acromegaly is a rare condition. It is caused when the pituitary gland makes too much growth hormone. The pituitary gland is a small endocrine gland attached to the bottom of the brain. It controls, makes, and releases several hormones, including growth hormone.

Usually a noncancerous (benign) tumor of the pituitary gland releases too much growth hormone.

In children, too much GH causes gigantism rather than acromegaly.

Symptoms

Symptoms of acromegaly may include any of the following:

  • Body odor
  • Blood in the stool
  • Carpal tunnel syndrome
  • Decreased muscle strength (weakness)
  • Decreased peripheral vision
  • Easy fatigue
  • Excessive height (when excess GH production begins in childhood)
  • Excessive sweating
  • Headache
  • Heart enlargement, which can cause fainting
  • Hoarseness
  • Joint pain, limited joint movement, swelling of the bony areas around a joint
  • Large bones of the face, large jaw and tongue, widely spaced teeth
  • Large feet (change in shoe size), large hands (change in ring or glove size)
  • Large glands in the skin (sebaceous glands) causing oily skin, thickening of the skin, skin tags (growths)
  • Sleep apnea
  • Widened fingers or toes, with swelling, redness, and pain

Other symptoms that may occur with this disease:

Exams and Tests

The health care provider will perform a physical exam and ask about your symptoms.

The following tests may be ordered to confirm diagnosis of acromegaly:

Other tests may be ordered to check whether the rest of the pituitary gland is working normally.

Treatment

Surgery to remove the pituitary tumor that is causing this condition often corrects the abnormal GH. Sometimes, the tumor is too large to be removed completely and acromegaly is not cured. In this case, medicines and radiation (radiotherapy) may be used to treat acromegaly.

Some people with tumors that are too complicated to remove by surgery are treated with medicines instead of surgery.

After treatment, you will need to see your provider regularly to make sure that the pituitary gland is working normally and that acromegaly does not come back. Yearly evaluations are recommended.

Support Groups

These resources may provide further information on acromegaly:

Outlook (Prognosis)

Pituitary surgery is successful in most people, depending on the size of the tumor and the experience of the surgeon.

Without treatment, the symptoms will get worse. Conditions such as high blood pressure, diabetes, and heart disease may result.

When to Contact a Medical Professional

Call your provider if:

  • You have symptoms of acromegaly
  • Your symptoms do not improve with treatment

Prevention

Acromegaly cannot be prevented. Early treatment may prevent the disease from getting worse and help avoid complications.

References

Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Endocrine disorders and cardiovascular disease. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 81.

Melmed S. Acromegaly. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 12.

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    Review Date: 5/7/2017

    Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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